Phospho Tau As a Diagnostic Biomarkers for Acute and Chronic TBI

Rubenstein R, Chang B, Yue JK, et al. Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers. JAMA Neurol. 2017;74(9):1063–1072. doi:10.1001/jamaneurol.2017.0655

In a cohort study, plasma samples from the TRACK-TBI pilot study were collected at a single time point from 196 patients with acute traumatic brain injury and 21 patients with severe traumatic brain injury admitted to receive inpatient rehabilitation. Plasma phospho-tau levels and phospho tau–total tau ratio during the acute phase and chronic traumatic brain injury were superior to total-tau levels for discriminating the severity and status of neurotrauma patients from healthy controls.